There is a DIRECT CORRELATION to Demodectic Mange & highly inbred dogs because of WEAKENED IMMUNE systems ....NO the dog SHOULD NOT be used in ANY breeding program....This is how we have " CURED " it in the past....Ivomec both orally & the drench , antibiotic injections & time, takes up to 6 months to " Cure " because this about controlling the mange mites....Make sure to use hot water when you drench the dog to open the pores so as to kill the mites, also let the dog to air dry, DO NOT , towel dry ...This keeps the Ivomec on the skin....