[quote=Presadam]Would you remove asymptomatic parents and siblings from a breeding program based on one puppy each, out of two different litters, having two unrelated health problems? (no other puppies known to have problems, no other relations known to have problems as yet) [/quote] First I would have all other siblings tested to find or rule out health issues with them. If none are found with them then it's obviously quite possible that each case might have been brought on by freak chance or environmental situations. I think would only be wise to overly scrutinize the pups produced from any of these breedings though.