Jaboa, I understand what you are trying to say and I hope I do not give a sense of hostility. I am not offended becuase I know there is a great mutual respect 8) . What I am trying to ask is; What do you or anyone think about a litter between a heavy/or moderate inbred Mastino and a outside breed, be it Mastiff, GD, or anything. 38% is a high number, but it should not be a suprise considering the Dogo Argentino since more and more people are breeding them. How many samples were accounted for the Neapolitan Mastiff? How does the term " loose connective tissue" relate to these scores? Thanks for the input Gillian and Tiago. What breed would you use? Mastino cross, APBT, DDB, SAB, PRESA, CC?