[quote=senor]What do you or anyone think about a litter between a heavy/or moderate inbred Mastino and a outside breed, be it Mastiff, GD, or anything. [/quote] As far as I'm concerned, first off it would depend on what the purpose of the breeding would be. If you're breeding a DDB to a Belgian Mal (for an extreme example), it's obviously a long shot for keeping a certian type, relative temerament, etc. so there should be at least SOME kind of forethought in exactly what the goal of improvement, or at least workability is. That said, I think outcrosses, generally, are a good thing for ANY breed. Once the stud books are closed the gene pool will only become more and more limited - especially in situations where a dog is studded out and bred to bitch after bitch simply because he has a show champion title.