droolyn, you listed 26 instances , out of 30-35 dogs. whether some of the dogs had more than one of these happen to them, which is worse, it doesnt matter , it is still a very high amount of degenerative health issues, not counting how many pups you got rid of that carry the genes, but you have lots of experience with your breed and you can contribute to the gene pool by better selection from what you have learned. i am sorry to hear that it is so difficult to get any consistancy of health from yours or impoted stock, but i see you are dedicated because you love the neopolitan mastiff. what sort of defects do you let slide and not cull for the sake of having dogs to breed to hope for pups without the defects, like cherry eye for example?