Advocate (the imidicloprid/moxidectin combo) is marketed under the tradename Advantage Multi in the U.S. It can be applied to puppies as young as 7 weeks that weigh at least 3 lbs. Safety in pregnant or lactating bitches has not been established. Moxidectin and doramectin are both in the same antiparasitic drug class: macrocyclic lactone. Other drugs in this class include ivermectin, abamectin, eprinomectin, selamectin, and milbemycin oxime. If you've got a case of demodectic mange and you feel compelled to treat it, why not just use ivermectin? It's probably the cheapest option, its from the same drug class, and much is known about its use in dogs. Judicious use of any of these compounds is warranted when treating collie breeds or mixes with unknown MDR1 gene mutation status.