The intact females I own(ed) have all had thier moods, raging from grumpy/pissy to lovie/passive. Each a little differant in thier own way. Be understanding give them privatcy when they need is. I don't train or condition females in heat. The stay i the house and get all the play time they want. I do keep the house temp. cooler durning these times. Personnaly, I woundn't give any pain drugs. The heat cycle is natural the dog needs to deal with it,