Several links about vaccination http://www.geocities.com/~kremersark/scottdoi.html http://www.canine-epilepsy-guardian-angels.com/chang_vac.htm http://www.ivis.org/advances/Infect_Dis_Carmichael/schultz/chapter_frm.asp?L A=1 As part of a minimum disease prevention program, every dog should receive CPV-2, CDV, CAV-2 and rabies vaccines at least one time at or after the age of 12 weeks (Table 2). If that were the only vaccination a dog ever received, and the products used were modified live CPV-2, CDV, CAV-2 and a 3-year killed rabies, the dog would have a >80% probability of developing immunity to those four viruses for 3 or more years.................. Coronavirus vaccines - Although approximately 50% of practices routinely use coronavirus vaccine, most vaccine experts agree that this vaccine is not needed. Some experts consider CCV vaccines useless. http://www.doglogic.com/vaccination.htm (Jean Dodds protocol) For breeds or families of dogs susceptible to or effected with immune dysfunction, immune-mediated disease, immune-reactions associated with vaccinations, or autoimmune endocrine disease (e.g., thyroiditis, Addison's or Cushing's disease, diabetes, etc.), the following protocol is recommended: see link for table ... .....After 1 year, annually measure serum antibody titers against specific canine infectious agents such as distemper and parvovirus. This is especially recommended for animals previously experiencing adverse vaccine reactions or breeds at higher risk for such reactions (e.g., Weimaraner, Akita, American Eskimo, Great Dane)........... ...............I do NOT use Bordetella, corona virus, leptospirosis or Lyme vaccines unless these diseases are endemic in the local area pr specific kennel. Futhermore, the currently licensed leptospira bacterins do not contain the serovars causing the majority of clinical leptospirosis today http://www.alternativevet.org/dog-diseases.htm#vaccination http://www.irishwolfhounds.org/vaccination.htm http://www.weim.net/homeovet/English/Vaccine.htm http://www.weim.net/homeovet/vaccstories.htm http://www.doglogic.com/vaccineinfo.htm#news "Dogs and cats immune systems mature fully at 6 months. If a modified live virus vaccine is given after 6 months of age, it produces an immunity which is good for the life of the pet (ie: canine distemper, parvo, feline distemper). If another MLV vaccine is given a year later, the antibodies from the first vaccine neutralize the antigens of the second vaccine and there is little or no effect. The titer is not "boosted" nor are more memory cells induced. http://www.vetinfo.com/dogvacc http://www.bccc.pair.com/vaccinat.htm http://www.altvetmed.com/pages/articles.html - click on Vaccination decisions http://www.itsfortheanimals.com/VACCINE1.HTM - scroll down to find........ For example, at 14 weeks of age, less than 5% of pups would have maternally derived antibody interference with one or more components in a combination vaccine, whereas at 6 weeks of age, more than 50 % of pups would be unable to mount an active immune response to one or more components in the vaccine http://www.labbies.com/immun.htm - very good links with tons of info Gelogd